We propose to use ISO for the study of Wolf-Rayet galaxies, which
 are the most extreme known examples of the starburst galaxy
 phenomenon.  Many of these galaxies harbor starbursts which have
 spawned thousands of O stars in times no greater than one million
 years.  The short time scale is inferred from the broad HeII 4686A
 line, indicative of short-lived Wolf-Rayet stars, which is seen in
 the integrated spectra of these galaxies.  We propose to use ISO
 to determine the luminosity of the starbursts, the nature of the
 interstellar environments in which they occur, and the dust
 content of their parent galaxies.  These observations will be done
 using 60 and 100um photometry from ISOPHOT, LWS spectroscopy of
 OI(63um) and CII(158um) emission lines, and 160um imaging
 photometry from ISOPHOT, respectively.  Use of the identical
 aperture for spectroscopy and photometry will permit direct
 measurement of the line to continuum flux ratio and comparison
 with model calculations and the properties of nearby galaxies.
 Many of these galaxies were absent or only weakly detected in the
 IRAS survey, and the predicted strengths of the OI and CII lines
 of even the brightest lie far below the currently achievable
 limits.  The high sensitivity achievable with ISO - a cooled
 telescope in space - is essential for these observations.
 Starburst galaxies will be very extensively studied with ISO,
 and our results on an extreme subset of starburst galaxies will
 thus represent an important contribution to one of ISO's most
 substantial investigations.