The scientific objective of this proposal is to study the physical and chemical properties of the dust grains associated with the Galactic cirrus. The combination of ISO and ground-based observations will allow us to obtain the FIR and submillimetric spectral energy distributions for a sample of high-latitude Galactic clouds which have an IR excess. Their spectral behaviour contains important information about the different dust components, the dust column density and the chemical and morphological properties of the particles. On the other hand, recent studies of laboratory cosmic analogs provide a fundamental support for the proposed ISO observations. In order to perform a comparative analysis between ISO observations, ground-based observations and laboratory results, the Laboratorio di Fisica Cosmica of Naples submits this proposal in collaboration with Nasa Ames Research Centers